Recognizing Cushing’s Disease in Dogs: 6 Common Clinical Signs

Cushing’s disease occurs when overly active adrenal glands (hyperadrenocorticism) produce too much glucocorticoids, a type of hormone secreted by the adrenal glands (located above the kidneys). In dogs, there are two common reasons the adrenal glands overly produce this hormone:

  1. Tumor of the Pituitary Gland – This type of Cushing’s disease is called pituitary-dependent hyperadrenocorticism (PDH). Pituitary tumors are responsible for about 85% of cases.
  2. Tumor of the Adrenal Gland – Tumors on one or both adrenal glands increase production of hormones. Adrenal tumors are responsible for 15% of cases.

Most likely to develop in middle-aged to senior dogs, Cushing’s disease is most commonly found in certain breeds including miniature poodles, dachshunds, beagles, Boston terriers, and boxers.

Cushing’s Disease in Dogs

Six Signs of Cushing’s Disease

  1. Excessive Drinking – Healthy dogs drinks an average of one cup of water per ten pounds of weight each day.
  2. Urination Issues – Frequent urination, inability to hold bladder, infections, and leaking.
  3. Ravenous Appetite – Sometimes, a big appetite indicates a health problem.
  4. Muscle Weakness – Protein cells are broken down in Cushing’s disease which causes lethargy or reluctance to jump.
  5. Pot-Bellied Appearance – Excess steroids result in a redistribution of fat around the abdomen.
  6. Skin and Fur Changes – Hair loss or a change in the appearance of your dog’s skin (wrinkling or darkening) can indicate a health concern.
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Canine Cushing’s Disease Diagnosis and Treatment

The presence of clinical signs is not enough evidence to diagnose Cushing’s disease. Common symptoms, however, can indicate the disease’s presence and that further lab testing should be completed. Treatment of Cushing’s disease can be complicated, as it requires frequent monitoring and adjustment based on the dog’s response and progress. If your dog is diagnosed with Cushing’s disease, speak with our veterinarian about our treatment and care options.

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